Adverse reactions to isosulfan blue dye and patent blue dye during sentinel lymph node mapping

Injecting Patent Blue Dye V for sentinel lymph node biopsy without skin staining

Use of Fluorescence Imaging in Combination with Patent Blue Dye versus Patent Blue Dye Alone in Sentinel Lymph Node Biopsy in Breast Cancer

PURPOSE Near-infrared fluorescence imaging with indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping in breast cancer. In this clinical trial, we compared the potential value of ICG combined with blue dye with that of blue dye alone for detecting SLNs. METHODS Patients undergoing SLN biopsy (SLNB) between November 2010 and November 2013 were included. Up to D...

Methylene blue dye, an accurate dye for sentinel lymph node identification in early breast cancer.

PURPOSE The aim of this prospective study was to analyze the safety of methylene blue dye (MBD) and compare its efficacy with that of isotopic mapping for sentinel lymph node (SLN) identification in breast cancer. PATIENTS AND METHODS The SLN procedure, involving isotopic mapping and MBD (subareolar intraparenchymal injections of 2 mL, 10 mg/mL), was performed on 100 patients with early breas...

Biphasic anaphylactic reaction to blue dye during sentinel lymph node biopsy

BACKGROUND Lymphazurin 1% blue dye can cause a severe anaphylactic reaction in approximately 1-3% of patients. CASE PRESENTATION We describe a case of intraoperative anaphylaxis resulting from Lymphazurin 1% blue dye. A 48-year old woman undergoing a mastectomy with sentinel lymph node biopsy experienced a biphasic anaphylactic reaction with two episodes of hypotension at 15 minutes and 2 hou...

Is blue dye still required during sentinel lymph node biopsy for breast cancer?

BACKGROUND In early breast cancer, the optimal technique for sentinel lymph node biopsy (SLNB) is the combined technique (radioisotope and Patent Blue V) which achieves high identification rates. Despite this, many centres have decided to stop using blue dye due to blue-dye-related complications (tattoo, anaphylaxis). We evaluated the SLNB identification rate using the combined technique with a...